THIOREDOXIN-INTERACTING PROTEIN-ACTIVATED INTRACELLULAR POTASSIUM DEPRIVATION MEDIATES THE ANTI-TUMOUR EFFECT OF A NOVEL HISTONE ACETYLATION INHIBITOR HL23, A FANGCHINOLINE DERIVATIVE, IN HUMAN HEPATOCELLULAR CARCINOMA

Introduction: Hyperactivated histone deacetylases (HDACs) act as epigenetic repressors on gene transcription and are frequently observed in human hepatocellular carcinoma (HCC).Although multiple pharmacological HDAC inhibitors (HDACis) have been developed, none is available in human HCC.Objectives: To investigate the pharmacological effects of a fa

PurposeThe study aimed to compare the 12-month post-operative outcomes of iStent and Body Spray iStent inject W (inject W), and the factors associated with their success in open-angle glaucoma.MethodsThis single-center, retrospective comparative case series evaluated the medical records of patients who underwent iStent (comprising 1 stent) or injec

We have developed much understanding of actin-driven cell migration and the forces that propel cell motility.However, fewer studies focused on estimating the effective forces generated by migrating cells.Since cells in vivo are exposed to complex physical environments with various barriers, understanding the forces generated by cells will provide i

The precedence of behavior bias-based studies with respect to investment is quite prevalent.Hence, a bibliometric analysis of available literature may lead to fresh topics in association with overconfidence bias.The literature ranging between 1970 and 2024 were scanned using terms related to overconfidence in finance as keywords to reach the relate